Principles and number of exclusions of NORIP reported data

See % remaining data at the end

Updated 13.05.2003

Only figures in yellow cells are summed at the end.

Data from remeasurements of LD and ALP by Odense, Danderyd and Fürst is not included.

Exclusion types Number of exclusions
Exclusions % of total Thawed serum % of all thawed serum
Based on control values 0 0.0% 0 0.0%
Series number lacking (i.e. no connection to control values) 2478 1.9% 313 0.5%
No method data submitted 665   440  
Duplicates: Same samples measured by different methods on same component 2252 1.8% 1659 2.65
Material difference: Automatic test of extreme differences between combinations of serum, plasma, fresh, thawed - the extreme value is excluded 1053 0.8% 375 0.6%
Person exclusions (extreme values for one or more components excludes the person), see Peter Feldings Iceland presentation
  Glucose > 11.0 mmol/L or

Glucose >7.0 mmol/L and fasting >8 hours

11 persons excluded        
  5s3s and 4s4s*:   17 persons excluded        
Sum No of persons excluded: 28 1161 1.5% 513 0.8%
Method exclusion
  Enzymes (see Heidi Steensland's Iceland precentation). Vitros results have been included later for all enzymes except LD, amylase and pancreatic amylase. 16946 16.0% 8399 17.6%
    Component

Serum and plasma, fresh and thawed

Serum, thawed

 
  Total number % excluded Total number % excluded
ALP 5008 84% 2477 80%
ALT 5656 15% 2869 15%
Amylase 4123 62% 2021 64%
AST 5148 12% 2452 12%
CK 5485 17% 2641 20%
GT 5339 47% 2557 45%
P-amylase 1617 34% 850 40%
LD 4707 100% 2376 100%
  Plasma with bad correlation with serum for method 1493 1.2% 0 0.0%
Component specific exclusions
  Fasting: Triglycerides, LDL, glucose 5532 4.3% 2770 4.4%
  Diabetes: Glucose 640 0.5% 275 0.4%
  Physical activity: CK 843 0.7% 374 0.6%
  Oestrogen use: TIBC 237 0.2% 156 0.2%
  Iron deficiency: Values < 6 umol/L 46 0.04% 19 0.03%
Other 65 0.05% 58 0.1%
  Large dispersion if reference values for TIBC 25 0.0% 25 0.0%
  One lab measured ionised Calsium instead of total calsium 21 0.0% 21 0.0%
  Manual test of extreme differences between combinations of serum, plasma, fresh, thawed - the extreme value is excluded 17 0.0% 11 0.0%
  Probably decimal point error 2 0.0% 1 0.0%
Exclusions by enzyme outier test (>M+4s as log transformed) 26   31  
Excluded  (less than the sum because some values have been excluded for more than one reason) 29514 23.4% 13053 21.3%
Total number of data 126213 100% 61335 100%

  * 5s3s: Results on thawed serum exceeding median (NORIP) + 5s (Malmø/Odense) for one component and median (NORIP)+ 3 s (Malmø/Odense) for another component. For 4s4s the limits are 4s for both components. s (as an estimation of total biological variation) were calculated from reference intervals used in Malmø 2001 with few exeptions. The 5s3s and 4s4s rules was not applied on low values of ALT, AST, CK, GT, ALP, LD , Creatinine, Carbamid(Urea), Triglycerides and/or Bilirubin

 

% of all data in database NOT excluded according to rules mentioned above

(updataed 24/1-2003, Pål Rustad)

18/3-2003: This table have not been updated for enzymes after inclusion of Vitros results (see table above)

Component

Plasma, thawed

Plasma, fresh

Serum, thawed

Serum, fresh

Na

91.6 %

94.4 %

95.6 %

93.4 %

K

89.5 %

85.8 %

94.6 %

90.4 %

Creatinin

94.8 %

94.1 %

97.3 %

93.3 %

Urea

94.9 %

84.9 %

98.1 %

93.7 %

Protein

88.2 %

90.5 %

94.7 %

90.6 %

Albumin

91.6 %

94.1 %

96.1 %

91.9 %

Glucose

38.1 %

51.9 %

39.0 %

49.6 %

Ca

92.6 %

89.8 %

95.1 %

90.9 %

Mg

92.4 %

94.2 %

96.6 %

92.7 %

P inorg

94.5 %

92.6 %

97.7 %

90.3 %

Uric acid

95.0 %

78.8 %

96.8 %

92.0 %

Cholesterol

94.8 %

95.7 %

98.9 %

94.0 %

Trigly

36.3 %

51.8 %

44.3 %

52.0 %

Bilirubin

70.0 %

65.2 %

97.2 %

93.2 %

ALP

0.0 %

0.0 %

0.0 %

0.0 %

Amylase

60.5 %

32.6 %

35.6 %

35.1 %

AST

74.3 %

72.7 %

65.8 %

74.3 %

Alt

59.7 %

60.1 %

60.4 %

72.7 %

CK

63.4 %

61.9 %

51.3 %

63.8 %

LD

0.0 %

0.0 %

0.0 %

0.0 %

Fe

93.0 %

94.9 %

97.5 %

93.8 %

TIBC

81.3 %

82.9 %

80.8 %

87.7 %

T4

97.1 %

25.0 %

97.7 %

No data reported

GT

46.9 %

38.3 %

33.2 %

38.2 %

TSH

97.1 %

25.2 %

98.3 %

No data reported

Ferritin

100.0 %

No data reported

98.5 %

100.0 %

P-Amylase

81.6 %

66.5 %

58.5 %

60.8 %

HDL

98.5 %

94.9 %

98.7 %

93.9 %